Presentation
Cognitive impairment (CI) is found in 40-70% of patients with multiple sclerosis (MS). CI in MS is an important contributor to employment status, quality of life, and social functioning. Therapeutic strategies for CI in MS are currently insufficient and require the development of novel approaches. In that context, the development of novel early biomarkers of CI in MS are of paramount interest.
This research project therefore aims at combining the expertise of the applicants’ group in magnetoencephalography (MEG) signal processing to specifically address the link between the alterations in stationary and non-stationary MEG resting state functional connectivity (rsFC) and CI in MS patients. For that purpose, we will first investigate and compare stationary and non-stationary MEG rsFC in MS patients and healthy subjects using an original combination of the methods developed at the applicants’ laboratories. We will then search for correlations between CI measures and MEG rsf-FC alterations.
Promoters
- Mark Woolrich, Oxford Centre for Human Brain Activity
- Serge Goldman and Xavier De Tiege, Faculty of Medicine, ULB
Thanks to the Foundation’s support, Martin Sjorgard has been hired at the ULB to work on this project.